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GSK159797-ICS Combo

GlaxoSmithKline plc

Drug Names(s): GSK159797-ICS Combo

Description: GSK159797 ('797) is an inhaled, long-acting (once-daily) Beta2 agonist (LABA). This type of drug relaxes smooth muscles in the airways, leading to airway dilation and increased air flow. It is to be combined with an inhaled corticosteroid (ICS). The specific one has not yet been released. Corticosteroids reduce inflammation.

Deal Structure: GSK159797 is a compound in the Beyond Advair collaboration between Theravance and GlaxoSmithKline (GSK), started in November 2002. The purpose is to develop once-daily long-acting beta2 agonists (LABAs) for the treatment of asthma and COPD. (Beyond Advair refers to a goal of replacing GSK's Advair, and inhaled twice-a-day combination LABA and inhaled corticosteroid [ICS].)

Each company contributed four LABA product candidates, which were pooled for development and eventual commercialization. A joint steering committee was formed to optimize the development of the compounds and their time to market. GSK has the responsibility to develop and commercialize one or more of the pooled compounds for use as a single agent and/or in combination medicines, utilizing GSK's proprietary drug delivery technology. GSK has exclusive, worldwide manufacturing and commercialization rights.

In connection with this collaboration, in 2002, Theravance received from GSK an upfront payment of $10...See full deal structure in Biomedtracker

Partners: Innoviva, Inc.


GSK159797-ICS Combo News


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