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JTE-151

Japan Tobacco Inc.

Drug Names(s): JTE151, JTE 151

Description: JTE-151 is an oral retinoid-related orphan receptor gamma antagonist which suppresses overactive immune response via inhibition of ROR gamma related to activation of Th17 cells (IL-17-producing T helper cells).

Deal Structure: JT and Orphagen
In January 2009, Orphagen Pharmaceuticals announced that it has entered into a Collaboration and License Agreement with Japan Tobacco to discover, develop and commercialize drugs in the areas of immunology and autoimmunity. Under the agreement, in effect since April 2008, JT has anexclusive license in Japan and options for exclusive licenses in the rest of the world. Financial terms were not disclosed.

Partners: Orphagen Pharmaceuticals


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