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PN 200

Aralez Pharmaceuticals Inc.

Drug Names(s): omeprazole and naproxen

Description: POZEN is developing a suite of proprietary product candidates, designated as its PN products platform, that combine an acid inhibitor, e.g., a proton pump inhibitor (PPI), with a non-steroidal anti-inflammatory drug (NSAID) in a single tablet. The products are intended to provide effective management of pain and inflammation with fewer gastrointestinal side effects and complications compared to an NSAID taken alone.

PN 200 combines the PPI Omeprazole with the NSAID Naproxen. Omeprazole, like other proton-pump inhibitors, blocks the enzyme in the wall of the stomach that produces acid. By blocking the enzyme, the production of acid is decreased, and this allows the stomach and esophagus to heal. Naproxen belongs to a class of drugs called non-steroidal anti-inflammatory drugs (NSAIDs). Naproxen blocks the enzyme that makes prostaglandins (cyclooxygenase ), resulting in lower concentrations of prostaglandins. As a consequence, inflammation, pain and fever are reduced.

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