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AB Science S.A.

Drug Names(s): AB8779

Description: AB8779 is a novel, small molecule spleen tyrosine kinase (SYK) kinase inhibitor. SYK is a tyrosine kinase that is a mediator of signaling in a variety of inflammatory cells, including mast cells, macrophage, dendritic cells (DC), natural killer (NK) cells, neutrophils, and B-cells.

Preclinical data demonstrate that AB8779 has biological activity in vitro and in vivoin inflammatory murine models of asthma and rheumatoid arthritis. Additionally, it was shown that AB8779induces apoptosis of B-cell chronic lymphocytic leukemia cells and has anti-tumoral activity in vivo in amouse model of mantle cell lymphoma (MCL). It was further demonstrated that AB8779 has nocardiotoxicity in vitro on both human and rat cardiomyocytes. In vitro safety pharmacology andpharmacokinectics studies have also demonstrated that AB8779 has goodbioavailability and an absence of mutagenic activity.

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