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Pfizer Inc.

Drug Names(s): Dofetilide, UK-68,798, UK-68798

Description: Dofetilide is a class III antiarrhythmic agent (see below). Specifically, it works by selectively blocking the rapid component of the delayed rectifier outward potassium current (IKr). This causes increase in the duration of the electrical impulse (action potential), primarily through an increase in the time tissue is refractory to a new impulse.

The Vaughan Williams Classification is as follows: I (blocks sodium channel; subclasses based on their effect on action potential duration), II (blocks beta-adrenergic receptors), III (blocks potassium efflux), IV (blocks L-type calcium channels, affecting conduction through the AV node between the upper and lower chambers of the heart), V (other).

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