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Drug Names(s): Amiodarone

Description: The precise mechanism of action of Cordarone (amiodarone) is unknown.

Cordarone is primarily a class III antiarrhythmic (see below), but also has class I, II, and IV effects. Among other things, it slows conduction and prolongs the refractoriness of tissue to a new electrical impulse. It has both an IV and oral formulation, which differ in some electrophysiological effects. The specific currents/receptors it blocks are: INa, ICaL, ICaT, IKr, Iks, IKATP, IKAch, If, and beta1R.

The Vaughan Williams Classification is as follows: I (blocks sodium channel; subclasses based on their effect on action potential duration), II (blocks beta-adrenergic receptors), III (blocks potassium efflux), IV (blocks L-type calcium channels, affecting conduction through the AV node between the upper and lower chambers of the heart), V (other).

Deal Structure: Cordarone was originally developed by sanofi and Wyeth.

The marketing exclusivity for Cordarone I.V. ended on October 11, 2002.

In January 2009, Pfizer and Wyeth announced that they entered into a definitive merger agreement under which Pfizer will acquire Wyeth in a cash-and-stock transaction currently valued at $50.19 per share, or a total of approximately $68 billion. The acquisition was completed in October 2009.

Partners: Pfizer Inc.

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