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Corvert

Pfizer Inc.

Drug Names(s): ibutilide fumarate

Description: Corvert is predominantly a class III antiarrhythmic (see below). Specifically, it blocks the IKr current and activates the INas current. Its primary effect is to prolong the duration of the electrical impulse traversing the heart (action potential) and the time where tissue is refractory to a new impulse. It is available in an IV formulation.

The Vaughan Williams Classification is as follows: I (blocks sodium channel; subclasses based on their effect on action potential duration), II (blocks beta-adrenergic receptors), III (blocks potassium efflux), IV (blocks L-type calcium channels, affecting conduction through the AV node between the upper and lower chambers of the heart), V (other).


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