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Drug Names(s): Sotalol
Description: Sotalol is considered by some to be a beta blocker (and, therefore, a class II antiarrhythmic agent-see below) because its primary action is on the ß-adrenergic receptors (it is not selective for the heart). However, sotalol also has inhibitory action on the outward potassium ion channels of the heart and so is also considered a class III antiarrhythmic agent. Sotalol prolongs repolarization, therefore lengthening the QT interval and decreasing automaticity. It also slows atrioventricular (AV) nodal conduction.
The Vaughan Williams Classification is as follows: I (blocks sodium channel; subclasses based on their effect on action potential duration), II (blocks beta-adrenergic receptors), III (blocks potassium efflux), IV (blocks L-type calcium channels, affecting conduction through the AV node between the upper and lower chambers of the heart), V (other).
Deal Structure: In 2006, Bayer acquired Schering AG.
Pink Sheet Berlex Betapace
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