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Aralez Pharmaceuticals Inc.
Drug Names(s): metoprolol succinate, Seloken
Description: TOPROL-XL is a beta1-selective (cardioselective) adrenoceptor blocking agent, for oral administration, available as extended release tablets. This preferential effect is not absolute, however, and at higher plasma concentrations, metoprolol also inhibits beta2-adrenoreceptors, chiefly located in the bronchial and vascular musculature. Metoprolol has no intrinsic sympathomimetic activity, andmembrane-stabilizing activity is detectable only at plasma concentrations much greaterthan required for beta-blockade. Beta blockers block the action of epinephrine and norepinephrine. As a result, they slow the heart rate, and slow conduction through the AV node between the atria and ventricles of the heart.
Aralez and AstraZeneca
In October 2016, Aralez Pharmaceuticals announced it will acquire the U.S. rights to Toprol-XL (metoprolol succinate) and its Authorized Generic (AG) pursuant to an agreement entered into between AstraZeneca and Aralez Pharmaceuticals. The agreement includes an initial upfront payment of $175 million, which will be financed through a previously committed senior secured debt facility with Deerfield Management. At closing, Aralez will also borrow funds under this credit facility to replenish $25 million that was paid from cash on hand in connection with the recently announced ZONTIVITY acquisition. In addition, Deerfield has agreed to provide Aralez access to up to an additional $250 million in capital to fund future mutually agreeable acquisitions. The transaction with AstraZeneca also includes mid-teen percentage royalties and up to $48 million of potential contingent milestone payments. In connection with the Asset Purchase Agreement, at closing the...See full deal structure in Biomedtracker
Partners: AstraZeneca PLC
Pink Sheet Toprol-XL FDA Reviewers
Pink Sheet Toprol-XL Clinical Protocols
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