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Prepandrix (with AS03 adjuvant)

GlaxoSmithKline plc

Drug Names(s): H5N1 (Avian Flu) Vaccine, H5N1 Vaccine (GSK), Pumarix (EU), Q-Pan H5N1, Adjupanrix

Description: Prepandrix is a prepandemic H5N1 (bird flu) vaccine made from inactivated (killed) H5N1 virus, using the AS03 adjuvant (squalene, DL-a-tocopherol, and polysorbate 80). The prepandemic strategy involves using the prepandemic vaccine to protect against a strain of flu that may cause a future pandemic, without actually knowing the strain ultimately responsible for the pandemic (where cross-protection may help). Prepandrix was originally approved on the basis of H5N1 data using the Vietnam strain. The use of GSK's proprietary AS03 adjuvant allows for a very low antigen dose to be used. Following a Scandanavian outbreak of narcolepsy in association with the administration of another AS03-containing vaccine (Pandremix), anti-AS03 antibodies were identified in approximately one quarter of affected individuals.

Both Prepandrix and Pumarix contain the AS03 adjuvant and the active antigen, A/Indonesia/05/2005 (H5N1).

Prepandrix (with AS03 adjuvant) News

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