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Epratuzumab - SLE

Immunomedics, Inc.

Drug Names(s): LymphoCide, hLL2, AMG412, IMMU-103

Description: Due to the UCB collaboration, BioMedTracker has separate drug profiles for Epratuzumab and Epratuzumab-SLE. Please also see Epratuzumab.

Epratuzumab is a humanized monoclonal antibody that targets the B cell specific antigen CD22.

Deal Structure: Immunomedics and Amgen
In December 2000, Immunomedics announced a partnership with Amgen to develop LymphoCide. Amgen will develop and market LymphoCide in North America and Australia. Amgen will be responsible for commercial manufacturing and will assume sponsorship of the U.S. INDs. Amgen will also receive rights to second-generation products including radiolabeled epratuzumab.

The agreement includes an $18 million up-front payment to Immunomedics and clinical milestone payments potentially totaling $65 million and royalties. The agreement provides for one-time sales milestone payments totaling $50 to $225 million if and when annual net sales reach $500 million to $1 billion.

In late 2003, both Amgen and Immunomedics announced that Amgen would not continue as a partner in the development of epratuzumab.

Immunomedics and UCB
In May 2006, Immunomedics and UCB announced a collaboration and license agreement for epratuzumab. The agreement...See full deal structure in Biomedtracker

Epratuzumab - SLE News

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