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Barasertib

AstraZeneca PLC

Drug Names(s): AZD1152

Description: AZD1152 is being evaluated to determine its effect as a specific inhibitor of Aurora kinase and its impact on cell division in proliferating tumors. It has been shown to inhibit spindle aggregation at the time of mitosis.

Deal Structure: AstraZeneca and BIND
In April 2013, AstraZeneca and BIND announced that they have entered into a strategic collaboration to develop and commercialise an Accurin based on AstraZeneca's prodrug Barasertib (AZD1152) with optimal critical nanoparticle properties such that a short infusion has the potential for extended target cover from increased biodistribution to the tumor site.

Under the terms of the agreement, the companies will work together to complete Investigational New Drug (IND)-enabling studies of the lead Accurin identified from a previously-completed feasibility program. AstraZeneca will then have the exclusive right to lead development and commercialization and BIND will lead manufacturing during the development phase. BIND could receive upfront and pre-approval milestone payments totaling $69 million, and more than $130 million in regulatory and sales milestones and other payments as well as tiered single to double-digit royalties on future...See full deal structure in Biomedtracker

Partners: Pfizer Inc.


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