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CRx-150

EPIRUS Biopharmaceuticals, Inc.

Drug Names(s): low dose amoxapine/dipyridamole

Description: CRx-150 is a combination of low doses of the approved drugs amoxapine and dipyridamole. Amoxapine is a tricyclic antidepressant, and dipyridamole is an anti-platelet drug. As an antidepressant, Amoxapine is thought to block the reuptake of norepinephrine and serotonin, and may block dopamine receptors, as well. Dipyridamole may inhibit red blood cell uptake of adenosine, phosphodiesterase, and thromboxane A2 formation. From preclinical studies, the low dose combination of the two is thought to inhibit the activity of inflammatory cytokines.

Deal Structure: Epirus and Zalicus
In April 2014, Epirus and Zalicus announced that they have entered into a definitive agreement under which Epirus will merge with Zalicus in an all-stock transaction. Following closing, Zalicus will be re-named Epirus Biopharmaceuticals.

In July 2014, EPIRUS Biopharmaceuticals announced the completion of a merger with Zalicus. The combined company, which has been renamed EPIRUS Biopharmaceuticals, will focus on the business of EPIRUS and operate under the leadership of the EPIRUS management team.


CRx-150 News


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