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Arsanis Biosciences GmbH

Drug Names(s): ASN 100, ASN-100

Description: ASN-100 is a fully human MAb cocktail in development for the prevention and treatment of infections due to severe noscomial Staphylococcus aureus including, methicillin-resistant (MRSA) and methicillin sensitive (MSSA) strains.

ASN100 is a combination of two monoclonal antibodies (ASN-1 and ASN-2) designed to neutralize six cytolysins that are important in the pathogenesis of both MRSA and MSSA infections. ASN-1 neutralizes Hla and four of the five leukocidins, HlgAB, HlgCB, LukSF and LukED. ASN-2 inactivates the 5th leukocidin, LukGH.

These cytolysins are used by S. aureus to kill neutrophils, monocytes and macrophages. Blocking the detrimental effect of leukocidins on WBCs and neutralization of Hla may reduce the virulence, invasiveness and pathogenicity of S. aureus and enhance the ability of the human host to eliminate bacteria.

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