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Drug Names(s): S6G5T-1, S6G5T-3, benzoyl peroxide/tretinoin
TWIN is a non-antibiotic topical cream for the treatment of acne vulgaris (acne). TWIN contains a fixed-dose combination of benzoyl peroxide and tretinoin, which are separately encapsulated in silica using Sol-Gel's proprietary technology. The silica microcapsule protects tretinoin from oxidative decomposition by benzoyl peroxide, thereby enhancing commercial shelf-life. The silica shell also controls the release rate of the drugs and creates a barrier between the drugs and the skin which could increase the tolerability of TWIN on acne-affected skin.
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