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Amgen, Inc.

Drug Names(s): ARC LPA, AD-01765

Description: ARC-LPA is a RNAi therapeutic from the Dynamic Polyconjugate (DPC) delivery platform that is designed to reduce production of Lp(a).

Deal Structure: Amgen and Arrowhead
Amgen and Arrowhead announced two license and collaboration agreements to develop and commercialize RNA interference (RNAi) therapies for cardiovascular disease. These are the first programs to utilize Arrowheads proprietary subcutaneous RNAi delivery platform.

Under one agreement, Amgen receives a worldwide, exclusive license to Arrowheads novel, RNAi ARC-LPA program. Under the second agreement, Amgen receives an option to a worldwide, exclusive license for a RNAi therapy for an undisclosed genetically validated cardiovascular target. In both agreements, Amgen will be wholly responsible for clinical development and commercialization.

Under the terms of the agreements taken together, Arrowhead will receive $35 million in upfront payments; $21.5 million in the form of an equity investment by Amgen in Arrowhead common stock; and up to $617 million in option payments, and development, regulatory and sales milestone payments. Arrowhead is...See full deal structure in Biomedtracker

Partners: Arrowhead Pharmaceuticals, Inc.


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