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Zika Vaccine Program (Vaxart)

Vaxart, Inc.

Drug Names(s): Zika Vaccine Program

Description: Vaxart's Zika Vaccine Program is an oral vaccine for the treatment of Zika virus. Vaxart vaccines are administered using room temperature-stable tablets that can be stored and shipped without refrigeration, are easy to administer and reduce medical waste. The foundation of Vaxart’s platform is a non-replicating adenovirus type 5 vector (Ad5). Circumventing pre-existing immunity is especially important for Ad5-based vaccines because a majority of the human population has circulating antibodies against adenovirus, with a significant proportion having neutralizing antibodies. Vaxart addresses this problem by delivering the Ad5-vectored vaccine via tablet directly to the gut, an organ that doesn’t induce the same sort of anti-vector immunity, thus avoiding any neutralization by blood- or muscle tissue-based immune cells.

This approach requires the use of an adjuvant, as protein vaccines are generally not effective in the gut. Vaxart has developed a patented adjuvant that works through a toll-like receptor (TLR). TLRs have been applied in vaccines and are well-accepted as effective immune stimulators. Vaxart uses a TLR known to be fully effective in the gastrointestinal tract and has “coupled” the adjuvant to the target antigen. The end result is a demonstrable immune response when administered orally.

Zika Vaccine Program (Vaxart) News

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