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MP4

Alexion Pharmaceuticals, Inc.

Drug Names(s): MP4

Description: MP4 is a recombinant fusion protein that mimics two components of myelin, the fatty nerve sheath damaged in multiple sclerosis patients. MP4 is a fusion of portions of myelin basic protein and proteolipid protein.

In theory, MP4 acts by inducing apoptosis (programmed cell death) in T cells that specifically recognize these myelin components and cause the destruction seen in multiple sclerosis patients. Alexion calls MP4 an “apogen,” or apoptosis-inducing antigen.

Preclinical studies show that MP4 has the potential to reduce the destruction of myelin by T cells. Clinical studies have been planned, and the FDA has accepted the MP4 IND. However, initiation of phase I studies has been on hold for five years as Alexion has attempted to find a partner to fund these trials.

Deal Structure: Alexion has been looking for a partner to develop MP4 for five years.


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