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Takeda Pharmaceutical Company Ltd

Drug Names(s): Tandemact (EU), glimepiride and pioglitazone (Actos), Sonias (Japan)

Description: Duetact is a combination of two diabetic drugs.

Pioglitazone (Actos) is a thiazolidinedione that decreases insulin resistance in the periphery and in the liver, resulting in increased insulin-dependent glucose disposal and decreased hepatic glucose output. Pioglitazone is a potent and highly selective agonist for peroxisome proliferator-activated receptor-gamma (PPARg). Activation of PPARg nuclear receptors modulates the transcription of a number of insulin responsive genes involved in the control of glucose and lipid metabolism.

Glimepiride is a sulfonylurea. Its primary mechanism of action appears to be dependent on stimulating the release of insulin from functioning pancreatic beta cells. In addition, extrapancreatic effects may also play a role in the activity of sulfonylureas such as glimepiride.

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