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364735

GlaxoSmithKline plc

Drug Names(s): S-364735, GSK364735

Description: 364735 is an integrase inhibitor which is thought to inhibit the integrase enzyme from inserting HIV viral DNA into the human gene. The integrase enzyme, one of three HIV enzymes required by the virus to reproduce, is unique to the virus and is not found in humans.

Deal Structure: Shionogi and GSK
In July 2001, Shionogi and GlaxoSmithKline announced a plan to form a joint venture to develop and market several drugs in clinical trials, including new agents to fight against HIV and neurological disorders.

Under the terms of a letter of intent, Shionogi and GSK plan to create a joint venture (JV) that will initially have exclusive rights to develop and commercialise four compounds contributed by Shionogi and one by GSK. The JV is expected to operate in the US and in major European markets. GSK will have exclusive marketing rights in countries where the JV does not operate, excluding Japan and Taiwan, where Shionogi will retain exclusive marketing rights to all Shionogi compounds. GSK will also have co-promotion rights in those JV markets where GSK's capabilities could enhance commercialisation efforts.

GSK and Shionogi will make milestone payments to the JV tied to the progression of the compounds contributed by the partner company. Both companies...See full deal structure in Biomedtracker

Partners: Shionogi & Co. Ltd.


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