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Sarepta Therapeutics, Inc.

Drug Names(s): AVI-5126

Description: Resten-CP is Resten-NG with AVI's proprietary CytoPorter (CP) attached to enhance delivery to the saphenous vein ex vivo before its use in bypass surgery.

Resten-NG is an antisense agent that targets the c-myc gene, which is believed to regulate the downstream genes that produce the pathology of restenosis: cell migration and adhesion, collagen formation, secretion of extra-cellular matrix, and cell proliferation, among others. The c-myc gene is immediately activated by the injury to the vascular lining during angioplasty and stent placement and peaks at 24 to 48 hours before subsiding. Resten-NG is a PPMO-based RNA (peptide–conjugated morpholino phosphorodiamidate oligomer), which uses morpholine rings instead of the standard nucleic acid rings in the backbones of RNA and DNA.

Resten-MP is a microparticle formulation of Resten-NG that can be delivered intravenously.

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