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Soliris

Alexion Pharmaceuticals, Inc.

Drug Names(s): eculizumab, 5G1.1

Description: BioMedTracker has separate drug profiles for Eculizumab. Please also see Eculizumab for asthma and dry AMD here.

Eculizumab is a humanized monoclonal antibody that targets the C5 component of complement. It is a construct similar to Alexion's lead drug, pexelizumab.

Deal Structure: Alexion contracted with Lonza to manufacture Eculizumab in January 2003.

In February 2008, Alexion agreed to acquire from Oklahoma Medical Research Foundation (OMRF) all rights to certain patents related to complement-inhibition technology. Alexion Pharmaceuticals Alexion will pay OMRF $10 million to acquire all rights and interests to the patents, in various amounts to be remitted in 2008 and the first half of 2009. No further amounts, including royalties, will be owed to OMRF in respect of sales of Soliris or other use of the OMRF patents.

DRI Capital
On an undisclosed date, DRI Capital purchased royalties relating to the sales of Soliris for paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome. As a result of this transaction, DRI Capital, through its managed private equity funds, owns royalty entitlements for this drug for an undisclosed rate.

Partners: Lonza Group Ltd. DRI Capital Inc.


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