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SPP200

Novartis AG

Drug Names(s): PEG-musirudin, pegmusirudin

Description: SPP200 (pegmusirudin), a pegylated recombinant protein, is a long-acting direct thrombin inhibitor. SPP200 is designed to prevent clot formation in the graft used in hemodialysis. It has a duration of action of over 100 hours and is not removed from the patient's body during dialysis (unlike unfractionated heparin).

Deal Structure: Abbott acquired SPP200 through the acquisition of Knoll AG in 2002 before out-licensing it to Speedel in 2003. In August 2006, Abbott Laboratories decided not to exercise its license-back option for SPP200 and thereby granted all development, commercialization and marketing rights for SPP200 to Speedel.

In September 2008, Speedel was acquired by Novartis.


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