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Roche Holding AG
Drug Names(s): isotretinoin, Roaccutane (EU)
Description: Accutane (Isotretinoin) is a retinoid.Retinoids exert their anti-neoplastic effects by regulating the expression of genes involved in cell growth, differentiation, apoptosis, tumor-associated angiogenesis, and host immune functions. Retinoids mediate the transcription of genes through retinoid nuclear receptors. Retinoid receptors are divided into retinoid X receptors (RXRs) and retinoic acid receptors (RARs). Isotretinoin acts primarily on the RAR family of receptors.
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