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Imara Inc.

Drug Names(s): IMR687, IMR 687

Description: IMR-687 is a highly potent, selective inhibitor of phosphodiesterase-9 (PDE9i) in blood cells. The company expects that decreased PDE9 activity will increase cGMP, a mechanism also targeted by hydroxyurea. IMR-687 was developed to target the same biochemical pathway as hydroxyurea, a chemotherapeutic agent, but without its safety issues.

The company reports that MR-687 has been shown in cell and animal models to increase fetal globin, which prevents the polymerization of the sickled hemoglobin. They note that this reduces red blood cell sickling, reduces red blood cell death and reduces occlusion of blood vessels. PDE9 inhibition also reduces white blood cell “stickiness” which further reduces the blockage of blood vessels.

IMR-687 News

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