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Drug Names(s): oestradiol, transdermal estradiol
Description: Estraderm releases estradiol through a rate-limiting membrane continuously upon application to intact skin. Binding of estradiol to estrogen receptors initiates translocation to the nucleus and and changes in gene expression via estrogen response elements.
Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary.
Pink Sheet Ciba's Vivelle
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