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Famvir

Novartis AG

Drug Names(s): AK-120, Famciclovir

Description: Famvir undergoes rapid biotransformation to the active antiviral compound penciclovir, which ahs inhibitory activity against cells infected with herpes simplex virus types 1 (HSV-1) or type 2 (HSV-2) or varicella zoster virus (VZV). In infected cells, viral thymidine kinase phosphorylates penciclovir to a monophosphate form that is converted to penciclovir triphosphate by cellular kinases. Penciclovir triphosphate inhibits HSV-2 DNA polymerase competitively with deoxyguanosine triphosphate. Consequently, herpes viral DNA synthesis and replication are selectively inhibited.

Deal Structure: Novartis and Asahi Kasei
In January 2008, Novartis granted Asahi Kasei the right to distribute Famvir in Japan pursuant to a Restated Distribution Agreement.

Asahi Kasei and Maruho
In April 2008, Asahi Kasei entered into a marketing alliance with Maruho for famciclovir in the Japanese Market.

Partners: Asahi Kasei Corporation Maruho Co., Ltd.


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