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Drug Names(s): Esidrex, hydrochlorothiazide
Description: Esidrix inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Esidrix also inhibits sodium ion transport across the renal tubular epithelium by binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihyperintensive mechanism of Esidrix is thought to be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle.
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