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Fenretinide (CerRx)

CerRx, Inc.

Drug Names(s): Fenretinide, 4-HPR, 4HPR, 4 HPR

Description: CerRx's fenretinide is an emulsion formulation of fenretinide (4-HPR), a synthetic retinoic acid derivative.

Sphingolipids are critical components of cell membranes. The key building blocks in the formation of the many kinds of sphingolipids are ceramides which exist in several forms, including dihydroceramides. Fenretinide increases toxic dihydroceramide in cancer cells by stimulating their de novo synthesis while simultaneously blocking their conversion to desaturated ceramides. Fenretinide does not cause dihydroceramide to build up in normal cells. Therefore, fenretinide is not toxic to normal cells and is better-tolerated in patients than many other anticancer agents.

Fenretinide (CerRx) News

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