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Novartis AG

Drug Names(s): methylphenidate hydrochloride

Description: Ritalin hydrochloride is a central nervous system stimulant. The exact mechanism of action in ADHD is unknown. The drug is thought to block the reuptake of norepinephrine and dopamine into the presynaptic neuron and increase the release of these monoamines into the extraneuronal space. In this way, ritalin hydrochloride presumably activates the brain stem arousal system and cortex to produce its stimulant effect.

Deal Structure: Celgene entered into an agreement with Novartis in April 2000 and receives royalties on all of Novartis' Ritalin family of ADHD-related products.

Partners: Celgene Corporation

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