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Simulect

Novartis AG

Drug Names(s): basiliximab

Description: Simulect functions as an IL-2 receptor antagonist by binding with high affinity to the alpha chain of the high affinity IL-2 receptor complex and inhibiting IL-2 binding. Simulect is specifically targeted against IL-2Ra, which is selectively expressed on the surface of activated T-lymphocytes. This specific high affinity binding of Simulect to IL-2Ra competitively inhibits IL-2-mediated activation of lymphocytes, a critical pathway in the cellular immune response involved in allograft rejection.

While in the circulation, Simulect impairs the response of the immune system to antigenic challenges. Whether the ability to respond to repeated or ongoing challenges with those antigens returns to normal after Simulect is cleared is unknown.


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