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Drug Names(s): Tripterygium wilfordii Hook F (TwHF)
Description: PMI-001 is an orally bioavailable, multi-mechanism botanical extract derived from the roots of the medicinal vine: Tripterygium wilfordii Hook F (TwHF). Extracts of TwHF have been used in Chinese allopathic medicine for the treatment of autoimmune and inflammatory diseases. Three diterpenoids—triptolide, tripdiolide, and triptonide are the most abundant and account for the immunosuppressive and anti-inflammatory effects observed with the root extracts in both in vitro and in vivo studies of TwHF. TwHF exerts its anti-inflammatory/immunosuppressant activities through synergistic modes of action including inhibition of IL-2, a-TNF, i-NOS, and COX-2 gene transcription.
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