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SB-649868

GlaxoSmithKline plc

Drug Names(s): GSK649868, GW649868

Description: GW649868 is an orexin antagonist. The orexins (hypocretins) are a peptide family comprised of two peptides, hypocretin-1 and hypocretin-2. Recent observations suggest an involvement of these peptides in the regulation of behavioral state. For example, these peptides are found in a variety of brain regions associated with the regulation of forebrain neuronal and behavioral activity states.

Deal Structure: This drug was discovered by GSK based on Human Genome Sciences technology. Human Genome Sciences is entitled to receive a milestone payment if the compound moves through clinical development into registration. Human Genome Scienes is also entitled to worldwide royalties of up to 10% if this compound is commercialized, and also has a 20% co-promotion option in North America and Europe.

In July 2012, GlaxoSmithKline and Human Genome Sciences entered into a definitive agreement under which GSK will acquire HGS for US$14.25 per share in cash. The acquisition was completed in August 2012.


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