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EMD 273063

Merck KGaA

Drug Names(s): hu14.18-IL2 fusion protein

Deal Structure: EMD 273063 (hu14.18-IL2) binds to ganglioside GD-2 to trigger an immune response. GD-2 is a disialoganglioside expressed on tumors of neuroectodermal origin, including human neuroblastoma and melanoma, with highly restricted expression on normal tissues, principally to the cerebellum and peripheral nerves in humans. The relatively tumor specific expression of GD-2 makes it a suitable target for immunotherapy with monoclonal antibodies or with artificial T cell receptors.


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