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Lexiva

GlaxoSmithKline plc

Drug Names(s): Fosamprenavir, FPV, GW433908, 908, VX-175, Telzir

Description: Lexiva (fosamprenavir calcium) is a prodrug of Agenerase, which inhibits HIV protease. A prodrug is a compound that is processed into an active drug inside the body.

Deal Structure: Vertex and Kissei
In April 1993, Vertex and Kissei Pharmaceutical signed an agreement to collaborate on the development of novel, orally active drugs for the treatment of HIV infection and AIDS. Kissei will develop and commercialize these compounds in Japan and the People's Republic of China and will pay Vertex a royalty on product sales in those countries. Kissei also has an option to acquire rights to Vertex HIV protease inhibitors in other Far Eastern countries. Vertex retains exclusive marketing rights to the compounds in North America, Europe and the rest of the world. In addition, Vertex retains manufacturing rights for bulk drug worldwide, including in the Kissei territories.

Vertex and GSK
In December 1993, Vertex and Wellcome signed an agreement to collaborate on the development of novel, orally active protease inhibitors for the treatment of HIV infection and AIDS. Under the terms of the agreement, Wellcome will make payments to Vertex up to $42...See full deal structure in Biomedtracker

Partners: Kissei Pharmaceutical Co., Ltd Pfizer Inc.


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