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Axovant Sciences, Inc.
Drug Names(s): RVT104
Description: RVT-104 is a combination of glycopyrrolate, a peripheral muscarinic receptor antagonist, and high-dose rivastigmine, a cholinesterase inhibitor, for the treatment of patients with dementia formulated with the company's Quaternary Ammonium Anti-Muscarinic – Cholinesterase Inhibitor (QAAM-CI) technology. Although details have not been released, QAAM-CI is designed to selectively inhibit acetylcholine outside the central nervous system to maximize aceylcholine levels in the brain.
Axovant and Qaam
Axovant and Qaam have entered into an exclusive license agreement under which Axovant expects to develop and commercialize products that combine cholinesterase inhibitors with peripheral muscarinic receptor antagonists including glycopyrrolate, which could mitigate the peripheral side effects of cholinesterase inhibitors.
Partners: Qaam Pharmaceuticals LLC
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