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Malarone

GlaxoSmithKline plc

Drug Names(s): atovaquone and proguanil hydrochloride

Description: The constituents of Malarone, atovaquone and proguanil hydrochloride, interfere with 2 different pathways involved in ATP and the biosynthesis of pyrimidines required for nucleic acid replication. Atovaquone is a selective inhibitor of parasite mitochondrial electron transport, and in Plasmodium species, a major target appears to be the cytochrome bc1 complex (Complex III). Proguanil hydrochloride primarily exerts its effect by means of the metabolite cycloguanil, a dihydrofolate reductase inhibitor. Inhibition of dihydrofolate reductase in the malaria parasite disrupts deoxythymidylate synthesis.


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