This web site is part of the Business Intelligence Division of Informa PLC
This site is operated by a business or businesses owned by Informa PLC and all copyright resides with them. Informa PLC’s registered office is 5 Howick Place, London SW1P 1WG. Registered in England and Wales. Number 8860726.
Drug Names(s): Atovaquone
Description: Mepron Suspension is a formulation of micro-fine particles of atovaquone, which have been reduced in size to facilitate absorption. Atovaquone is a highly lipophilic drug that closely resembles the structure of ubiquinone. The mechanism of action of Mepron against Pneumocystis carinii has not been fully elucidated. In Plasmodium species, the site of action appears to be the cytochrome bc1 complex (Complex III), in the mitochondria. Several metabolic enzymes are linked to the mitochondrial electron transport chain via ubiquinone. Inhibition of electron transport by atovaquone will result in indirect inhibition of these enzymes. The ultimate metabolic effects of such blockade may include inhibition of nucleic acid and ATP synthesis.
Pink Sheet Glaxo Wellcome Malarone
Pink Sheet In Brief: Mepron tablets
Pink Sheet Glaxo Wellcome Mepron
Additional information available to subscribers only: