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Amgen, Inc.

Drug Names(s): T487

Description: T487’s putative mechanism of action includes chemokine receptor inhibition. Such action at the level of lymphocytes can provide pharmacological anti-inflammatory action. Tularik initially hopes to develop T487 in rheumatoid arthritis and psoriasis, with potential future investigation in inflammatory bowel disease. A wealth of preclinical studies supports this strategy, but substantive peer-reviewed publications regarding this specific compound are currently unavailable.

Deal Structure: In 1999, Tularik and ChemoCentryx partnered to develop T487. Tularik retains worldwide commercialization rights; ChemoCentryx receives royalties and milestone payments.

Amgen acquired T487 on August 13, 2004 through Amgen's acquisition of Tularik.

Partners: ChemoCentryx, Inc.

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