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MK-0752

Merck & Co., Inc.

Drug Names(s): MK-0752

Description: MK-0752 is a potent gamma secretase inhibitor. Gamma secretase catalyzes the cleavage of the Notch receptor within the transmembrane domain thereby releasing the Notch intracellular domain, which translocates to the nucleus to activate transcription of target genes. Gamma secretase inhibitors can induce G0/G1 arrest, thus inducing apoptosis.


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