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MK-0724

Merck & Co., Inc.

Drug Names(s): ONO-2506, Arocyte, Arundic acid

Description: MK-0724 is a drug to prevent the expansion ofcerebral infarction by improving functionof astrocytes, a type of support cell in thebrain that is involved in repair and scarring. MK-0724 inhibits synthesis of calcium binding protein S100B in astrocytes. S100B has detrimental effects on cell survival through activation of various intracellular signaling pathways. Another potential mechanism is that MK-0724 restores the activity of astroglial glutamate transporters by enhanced genetic expression.

Deal Structure: Ono and Merck
In November 2004, Ono signed an agreement with Merck to out-license ONO-2506 (injectable formulation), a novel compound originally synthesized and developed by Ono for the treatment of acute stroke. Under this arrangement, Ono will receive rights to MK-0431 and to aprepitant (MK-0869) for the treatment of cancer chemotherapy-induced nausea and vomiting from Merck.

Ono granted Merck an exclusive license for development and marketing of ONO-2506 (injectable formulation) and its backup compound in countries around the world (excluding Japan, South Korea and Taiwan). Under the terms of the agreement, Ono will receive an initial payment and milestone payments in addition to royalties on net sales of ONO-2506 (injectable formulation). If Merck obtains additional indications and/or products under the license, Ono will receive additional milestone payments. Ono will supply the drug to Merck as unpackaged product.

Partners: Ono Pharmaceutical Company, Ltd.


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