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Merck & Co., Inc.

Drug Names(s): Lisinopril and hydrochlorothiazide

Description: Prinzide is a combination of the angiotensin converting enzyme inhibitor (ACEI) lisinopril and the diuretic hydrochlorothiazide. ACEIs work by preventing angiotensin I from converting into a more potent form that increases salt and water retention in the body and constricts blood vessels, though other mechanisms, such as inhibiting the degradation of the vasodilator bradykinin, may be involved in their longer term effects. Hydrochlorothiazide is a diuretic: it acts at the distal renal tubules of the kidney to increase salt and hence urine excretion, thereby reducing the volume of fluids in the circulation.

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