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Aspen Pharmacare Holdings Limited

Drug Names(s): Bulsufan

Description: Busulfan is a chemotherapeutic agent commonly used as part of a conditioning regimen in the transplant setting. Busulfan is a bifunctional alkylating agent in which two labile methanesulfonate groups are attached to opposite ends of a fourcarbon alkyl chain. In aqueous media, busulfan hydrolyzes to release the methanesulfonate groups. This produces reactive carbonium ions that can alkylate DNA. DNA damage is thought to be responsible for much of the cytotoxicity of busulfan.

Deal Structure: In May 2009, GSK announced that it will divest eight specialist medicines to Aspen Pharmacare Holdings, including Alkeran (excluding US), Leukeran, Myleran and Purinethol.

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