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GlaxoSmithKline plc

Drug Names(s): Trifluoperazine

Description: Stelazine is a typical or first generation antipsychotic. It blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain (in the ventral striatum); depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.

Regarding antipsychotic/antianxiety effects, observations suggest that Stelazine's primary action is to depress the physiologic accompaniments of the emotional factors of the personality which are believed to be basically evoked by the limbic system and its connections with the hypothalamus. Evidence indicates that the phenothiazines like Stelazine act on the subcortical areas of the CNS which influence the affective functions. Stelazine is specific in its activity and its effects seem limited to parts of the basal ganglia, such as the amygdaloid nucleus.

In terms of antiemetic effects, Stelazine inhibits indirect stimulation of the vomiting center, but does not inhibit indirect stimulation of the center by gastrointestinal stimulants. Because of this, it is believed that its site of action is the chemoreceptor trigger zone.

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