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Zucara Therapeutics, Inc.

Drug Names(s): PRL 2903, PRL2903

Description: PRL-2903 is a somatostatin type 2 (SSTR2) receptors blocker, under development by Zucara therapeutics for the prevention of hypoglycemia in people with diabetes.

The company was founded based on research that these receptors are stimulated at a higher than normal level by over-production of somatostatin in insulin-dependent diabetic patients. The effect of this dysregulated somatostatin on alpha-cells is to suppress glucagon secretion, which results in the insulin-dependent diabetic patient being unable to avoid or recover from hypoglycemia.

Thus, the drug is intended to prevent dangerous low blood sugar by restoring the body's ability to counter-regulate hypoglycemia.

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