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Actelion Pharmaceuticals Ltd.

Drug Names(s): ACT 840, ACT840, ACT 451840, ACT-451840, ACT451840

Description: ACT-840 (ACT-451840) is under development by Actelion, as an oral suspension for the treatment of malaria at early Plasmodium falciparum blood stage infection.

In preclinical studies, ACT-451840 proved to be highly effective against Plasmodium falciparum and Plasmodium vivax. It has also activity against parasites that have developed resistance against current standard therapies. ACT-451840 appears to have a mode of action distinct from current antimalarial drugs, including artemisinins and quinolones. The drug has a rapid onset of action, no erythrocytic stage specificity, and shows reduction of gametocyte infectivity.

ACT-840 News

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