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Zantac

Teligent, Inc.

Drug Names(s): Ranitidine hydrochloride

Description: Zantac is a competitive, reversible inhibitor of the action of histamine at the histamine H2-receptors, including receptors on the gastric cells. The H2 antagonists suppress the normal secretion of acid by parietal cells and the meal-stimulated secretion of acid. They accomplish this by two mechanisms: histamine released by Enterochromaffin-Like (ECL) cells in the stomach is blocked from binding on parietal cell H2 receptors which stimulate acid secretion, and other substances that promote acid secretion (such as gastrin and acetylcholine) have a reduced effect on parietal cells when the H2 receptors are blocked.

Deal Structure: GlaxoSmithKline and Covis
In December 2011, Covis Pharma Sarl announced an agreement with GlaxoSmithKline to acquire full commercial rights for Fortaz (ceftazidime), Zinacef (cefuroxime), Lanoxin (digoxin), Parnate (tranylcypromine sulfate), and Zantac Injection (ranitidine hydrochloride) in the United States and Puerto Rico. GlaxoSmithKline will retain the existing rights for these products in countries outside the United States. Terms of the agreement have not been disclosed. GSK will manufacture and supply Fortaz Injection, Zinacef Injection, Parnate, and Zantac Injection to Covis. Lanoxin Tablets and Injection, Fortaz Frozen, Zinacef Frozen and Zantac Injection Premixed will continue to be manufactured and supplied by current third-party suppliers.

Covis and Concordia
In March 2015, Concordia Healthcare announced it has entered into a definitive asset purchase agreement to acquire substantially all of the commercial assets of privately held Covis...See full deal structure in Biomedtracker

Partners: GlaxoSmithKline plc


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