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Zymafos

ZIOPHARM Oncology, Inc.

Drug Names(s): ZIO-201, isophosphoramide mustard (IPM), palifosfamide

Description: Ziopharm is also developing an oral formulation. Please see Oral Palifosfamide.

Palifosfamide is a stabilized IPM (isophosphoramide mustard). IPM is a proprietary stabilized metabolite of ifosfamide. Ifosfamide is a structural analogue of cyclophosphamide and its mechanism of action is presumed to be identical. The main effect of cyclophosphamide is due to its metabolite phosphoramide mustard. Phosphoramide mustard forms DNA crosslinks between and within DNA strands. This leads to cell death.


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