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Cumberland Pharmaceuticals Inc.

Drug Names(s): Amifostine

Description: The active ingredient of Ethyol, amifostine, is an aminothiol that is thought to have cytoprotective effects through various mechanisms.It binds to platinums and alkylating agents; it scavenges free radicals that can damage cells; and it upregulates p53 thereby reducing apoptosis.

Deal Structure: Scherico is the exclusive distribution partner for Ethyol in the countries comprising the European Territories. Scherico and other affiliates of Schering have various other licensing and distribution arrangements for Ethyol and NeuTrexin outside of the United States.

Since October 1, 2001, MedImmune has been the sole marketer of Ethyol in the United States. Prior to this date, Ethyol was co-promoted by MedImmune and ALZA Corporation (ALZA). Outside the United States, the Company has various distribution and marketing arrangements for Ethyol, primarily with affiliates of Schering-Plough Corporation (Schering). The product has been approved in 60 countries worldwide.

The Company acquired U.S. marketing rights to Ethyol from ALZA, effective October 1, 2001. Previously, ALZA was responsible for sales and marketing of Ethyol in the U.S. under a December 1995 co-promotion agreement between the two companies. In accordance with the original agreement, MedImmune Oncology will...See full deal structure in Biomedtracker

Partners: Johnson & Johnson Merck & Co., Inc. AstraZeneca PLC Clinigen Group plc

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