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Drug Names(s): MEDI507, MEDI-507
Description: Siplizumab is a humanized monoclonal antibody that binds to the CD2 receptor found on the surface of T-cells and natural killer (NK) cells. By binding to CD2, siplizumab selectively suppresses the function of T-cells and NK cells. T-cells are an essential part of the pathophysiology of psoriasis, and it is believed that modulation of T-cell activities may be therapeutically advantageous in the treatment of psoriasis.
Deal Structure: Siplizumab was originally developed by MedImmune; in June 2007, AstraZeneca closed its acquisition of MedImmune.
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